It is important to distinguish digital instruments by type of sound generation.
I prefer instruments with physical modeling and certain synthesizers.
All these instruments can be played in the just intonation.
Therefore they are suitable for Natural Pure Tuning.
More digital instruments with professional tuning options:
Software for Live Performance and Production
Gig Performer for Live Performance
Cubase and Wavelab for Production
Cubase and Wavelab are my favourite tools for production.